癌症治疗监测使用无细胞DNA碎片组
Iris van 't Erve1, Bahar Alipanahi2, Keith Lumbard2
1Department of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Nature communications
|October 21, 2024
概括
一种新方法,DELFI-瘤分数 (DELFI-TF),使用无细胞DNA (cfDNA) 碎片组来估计瘤负担. 这种独立于瘤的方法准确地预测了癌症治疗反应和患者的存活率,优于传统的成像方法.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 生物标志物 生物标志物
背景情况:
- 目前用于癌症监测的循环无细胞DNA (cfDNA) 测定通常需要识别瘤特异性突变.
- 这限制了它们在突变无法检测或未知的场景中的应用.
研究的目的:
- 为监测癌症开发和验证一种瘤独立和突变独立的cfDNA试验.
- 评估这种新方法在预测治疗反应和患者存活率方面的有用性.
主要方法:
- 开发DELFI-瘤分数 (DELFI-TF) 测定方法,使用cfDNA的低覆盖全基因组测序.
- 在结直肠和肺癌患者的独立队列中进行验证.
主要成果:
- 德尔菲-TF得分与循环瘤DNA (ctDNA) 水平有很强的相关性,即使突变无法检测到.
- 治疗前的DELFI-TF得分预测了临床反应,并且是整体存活率的独立预测指标.
- 在治疗期间较低的DELFI-TF得分与较长的整体存活率有关,并且比成像更准确地预测结果.
结论:
- 在DELFI-TF测定有效估计使用cfDNA碎片组的瘤负担.
- 这种独立于瘤的方法显示了监测治疗反应和预测癌症患者的临床结果的巨大潜力.
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