相关实验视频

Updated: Jul 16, 2026

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow
11:26

Real-time Imaging of Endothelial Cell-cell Junctions During Neutrophil Transmigration Under Physiological Flow

Published on: August 14, 2014

19.5K

在炎症反应期间,G-CSFR诱导的白细胞透细胞迁移受ICAM1-PKCa轴的调节:基于多组组合分析

Zhipeng Zhu1,2, Xiaoyan Ling3, Gaojian Wang4

  • 1Department of Anesthesiology, Run Run Shaw Hospital, Zhejiang University School of Medicine, Shangcheng District, Qingchun East Road 3, Hangzhou, 310016, China. xiaozhu781126@zjxu.edu.cn.

Cell biology and toxicology
|October 21, 2024
PubMed
概括

颗粒细胞殖民地刺激因子 (G-CSF) 调高细胞间细胞粘附分子-1 (ICAM1) 和调低PKCa,在炎症期间驱动白细胞超内皮迁移 (TEM). 这个ICAM1PKCa轴是G-CSF诱导的TEM的一个关键目标.

关键词:
内皮细胞是内皮细胞.颗粒细胞殖民地刺激因子炎症反应是一种炎症反应.细胞间细胞粘附分子-1-1白细胞的跨内皮细胞迁移.

更多相关视频

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.2K
Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration06:42

Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration

Published on: May 24, 2024

1.3K

相关概念视频

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Acute Inflammation II: Cellular Phase01:26

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...