阿伦德罗纳酸在患有状细胞病和骨质疏松症的成年人中保持骨矿物质密度
Oyebimpe O Adesina1, Isaac C Jenkins2, Fábio Galvão3
1Division of Hematology and Oncology, University of California, Davis School of Medicine, 4501 X Street, Suite 3016, Sacramento, CA, 95817, USA. adesina@ucdavis.edu.
概括
在患有状细胞病 (SCD) 和骨质疏松症的成年人中,使用阿伦德罗纳特显示腰椎骨密度稳定,副作用大多轻微. 长期使用可能会改善骨密度,但发现了一例不典型骨折.
科学领域:
- 骨代谢和骨质疏松症研究研究
- 血液学和状细胞疾病管理管理
背景情况:
- 低骨矿物质密度 (BMD) 在状细胞病 (SCD) 中很常见.
- 对维护SCD成人的骨质质量的双酸盐的疗效和安全性尚未得到充分证实.
研究的目的:
- 评估阿伦德罗纳酸对成年人状细胞病 (SCD) 和骨质疏松症的骨矿物密度 (BMD) 的影响.
- 评估alendronate治疗在这个患者群体中的安全性和耐受性.
主要方法:
- 对64名患有SCD和骨质疏松症的成年人用alendronate治疗的临床数据的回顾性审查.
- 骨矿物质密度 (BMD) 用双能X射线吸收计 (DXA) 在腰椎,大腿部和全部进行测量.
- 分析按治疗持续时间,性别,骨部位和SCD基因型分层的BMD变化.
主要成果:
- 腰椎骨髓 BMD 在使用阿伦德罗纳特时保持稳定,在接受治疗超过5年的患者中显示出显著的变化.
- 女性在部部和部总部的BMD基线比男性更低,但ALENDRONATE的BMD变化在性别之间没有显著差异.
- 大多数与治疗相关的副作用是轻微的和自我限制的;偶尔注意到一种非典型的股骨骨折病例.
结论:
- 在患有SCD和骨质疏松症的成年人中,阿伦德罗纳特治疗没有显示出性别和BMD变化之间的显著相互作用.
- 在接受阿伦德罗纳酸治疗不到5年的患者中,腰椎骨髓骨质量是稳定的.
- 虽然一般耐受性很好,副作用轻微,但不典型骨折的可能性值得考虑.
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