基于数学功能控制的3D打印平板电脑的开发和对药物释放的影响
Honghe Wang1, Indrajeet Karnik1, Prateek Uttreja1
1Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS, 38677, USA.
Pharmaceutical research
|October 21, 2024
概括
3D打印的平板电脑表面几何精确地控制药物释放率. 数学函数调整了药片形状,证明了个性化医疗应用的表面曲率和溶解速度之间的直接相关性.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 3D打印提供了个性化药物递送的潜力,但在控制药物释放方面面临挑战.
- 精确控制药物释放概况对于优化治疗疗效和患者遵守至关重要.
研究的目的:
- 应用表面方程来构建3D打印平板电脑模型.
- 调整功能参数并创建多个平板电脑模型.
- 为了将模型参数与体外药物释放行为的相关性.
主要方法:
- 开发了3D打印的平板电脑,使用融沉积建模 (FDM) 和热挤出 (HME).
- 有控制的平板电脑表面几何形状,具有调节药物释放的数学功能.
- 通过变化的抛物线表面深度生产的片 (T1-T5),以评估曲率对溶解的影响.
主要成果:
- T5配方 (最大曲率) 显示了最快的药物释放 (在4小时内完成).
- T1和T2药片的释放速度较慢 (大约6小时).
- 证实了表面积和药物释放率之间的相关性,与Noyes-Whitney方程保持一致.
结论:
- 精确控制药片表面几何形状,有效地定制药物释放配置文件.
- 这种方法提高了患者的服从性和治疗疗效.
- 提供一个可复制和适应的平台,以优化药物输送在个性化医学.
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