用银金纳米粒子装载的基于环氧的实验性内牙密封剂的抗菌和细胞毒性特征:体外研究:实验室研究
Nermine Hassan1, Mona Riad2, Shereen Hafez Ibrahim3
1Lecturer of Endodontics, Faculty of Dentistry, Cairo University, Giza, Egypt.
BDJ open
|October 21, 2024
概括
银金纳米颗粒显示出对Enterococcus faecalis和低细胞毒性有前途的抗菌作用,使其适用于牙科应用. 这些纳米颗粒可以用作道预处理或纳入AH Plus密封剂以提高牙科材料性能.
科学领域:
- 牙科材料科学 牙科材料科学
- 在牙科的纳米技术.
- 生物相容性研究 生物相容性研究
背景情况:
- 将纳米颗粒纳入牙科材料的目的是增强抗菌性质.
- 评估这些新材料对关键口腔组织的潜在毒性对于防止二次损伤至关重要.
研究的目的:
- 评估一种以环氧树脂为基础的内牙密封剂 (AH Plus) 的长期抗菌疗效和细胞毒性,该密封剂与银金纳米颗粒 (Nano Care Plus Silver Gold®) 进行了修改.
主要方法:
- 测试组:纳米护理金,修改AH Plus (mAH Plus) 和对照AH Plus.
- 使用阿加扩散对Enterococcus faecalis进行评估的抗菌活性.
- 细胞毒性通过MTT测定评估,按照ISO-10993-5指南在基线,2周和4周.
主要成果:
- 抗菌活性在48小时和72小时显示出统计学上显著的差异,纳米护理金表现出更高的疗效.
- 细胞毒性结果表明组之间存在显著差异 (p<0.001),AH Plus对照组最初显示较高的值.
- AH Plus和纳米黄金混合物随着时间的推移表现出稳定的生存能力,表明良好的生物相容性.
结论:
- 银金纳米颗粒具有有利的抗菌特性和低细胞毒性.
- 这些纳米颗粒适合用作道预处理剂.
- 将银金纳米颗粒纳入AH Plus密封剂是改善牙科材料性能的一种可行的选择.
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