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葡萄糖对乳腺脂肪细胞和癌细胞之间的相互重编程产生影响

Maria Rosaria Ambrosio¹, Michiel Adriaens², Kasper Derks³

¹Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy. mariarosaria.ambrosio@cnr.it.

Scientific reports

|October 21, 2024

概括

乳腺癌细胞在高葡萄糖条件下与脂肪细胞相互作用时重编程其新陈代谢,积累脂质并获得类似干细胞的特性. 这种相互作用会影响治疗反应,并突出显示脂肪细胞可塑性作为治疗点.

科学领域:

在瘤学瘤学.
代谢研究研究代谢研究
细胞生物学细胞生物学

背景情况:

癌细胞表现出代谢重编程,特别是葡萄糖吸收增加.
瘤微环境中的脂肪细胞会影响乳腺癌 (BC) 的进展.
肥胖和糖尿病与较高的BC发病率和死亡率有关.

研究的目的:

为了研究乳腺癌细胞和脂肪细胞之间的相互作用.
为了确定葡萄糖水平对这种交叉语音的影响.
了解脂肪细胞如何在不同的葡萄糖条件下影响BC细胞,反之亦然.

主要方法:

乳腺脂肪基衍生中酶体干细胞 (MAd-MSCs) 分化为脂肪细胞.
在正常血糖 (5.5mM) 和高血糖 (25mM) 的葡萄糖条件下与ER+BC细胞共同培养脂肪细胞.
在单种和共同培养中通过RNA-Seq对两种细胞类型的转录组概况.

主要成果:

在高葡萄糖的共同培养中重新编程BC细胞,诱导脂质积累和茎状性质,同时减少Tamoxifen的反应能力.
当葡萄糖水平下降时,BC细胞诱导脂肪细胞脱脂和多能性增长.
脂肪细胞影响BC细胞转录组,以依赖葡萄糖的方式促进攻击性和干性.

结论:

调节周围瘤脂肪细胞可塑性对于在有代谢失衡的患者中阻止BC进展至关重要.
受葡萄糖影响的BC-脂肪细胞对话驱动瘤攻击性的关键方面.
了解代谢交叉交谈为乳腺癌提供了潜在的治疗策略.

关键词:

增脂生殖是一种增脂的过程.乳腺癌乳腺癌乳腺癌葡萄糖是一种葡萄糖.乳腺脂肪细胞乳腺脂肪细胞转录的签名转录的签名瘤微环境瘤微环境

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