在2型糖尿病患者中,红细胞叶酸与糖尿病病之间的关联:一个横截面研究
Peixia Yu1, Yongjin Ji2, Hairu Wang1
1Department of Laboratory Medicine, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Scientific reports
|October 21, 2024
概括
较高的红血细胞 (RBC) 叶酸水平与2型糖尿病 (T2DM) 患者糖尿病病 (DN) 的风险增加有关. 这一发现表明,红细胞叶酸是DNA叶酸状况的关键指标.
科学领域:
- 营养生物化学 营养生物化学
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 叶酸是代谢途径中必不可少的辅助因子,影响甲基化和核酸合成.
- 糖尿病病 (DN) 是糖尿病 (DM) 的严重并发症.
- 红细胞 (RBC) 叶酸水平和DN之间的关系还不清楚.
研究的目的:
- 研究红细胞叶酸水平与2型糖尿病 (T2DM) 的成年人中DN的存在之间的关联.
主要方法:
- 采用2011-2018年国家健康和营养检查调查 (NHANES) 数据进行的横截面研究.
- 包括3070名患有T2DM的成年人,分析人口统计数据,叶酸和维生素B12水平,食叶酸摄入量和实验室结果.
- 采用后勤回归,平滑曲线拟合和相互作用效应分析来评估关联.
主要成果:
- 在红细胞叶酸水平和DN之间发现了显著的正相关性 (P < 0.001).
- 在调整了混变量后,较高的红血细胞叶酸水平仍然与增加DN风险相关 (OR: 1.38,95%CI: 1.27-1.49,P < 0.001).
- 曲线拟合证实了红细胞叶酸和DN风险之间的线性关系,没有显著的非线性 (P = 0.147).
结论:
- 红血球叶酸水平升高与T2DM患者患DN的风险更高有关.
- 红血球叶酸状况应被认为是监测糖尿病患者DN风险的重要指标.
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