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Updated: Jun 9, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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用LABEL-seqq进行细胞内蛋白质丰度,活性,相互作用和药物可用性的多重分析

Jessica J Simon1, Douglas M Fowler2,3,4, Dustin J Maly5,6

  • 1Department of Chemistry, University of Washington, Seattle, WA, USA.

Nature methods
|October 21, 2024
PubMed
概括

我们开发了LABEL-seq,这是一种新型检测方法,用于分析人体细胞中的蛋白质变体. 该方法测量蛋白质活性,相互作用和药物可用性,为癌症机制和药物开发提供了洞察力.

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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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