肠道微生物对儿童过敏性鼻炎和室内灰尘虫IgE反应的影响
Junyang Li1, Nan Shen2,3, Wenjun He1
1Department of Otolaryngology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Pediatric research
|October 21, 2024
概括
患有室内灰尘虫过敏性鼻炎 (AR) 的儿童有改变的肠道细菌,特别是较低水平的Escherichia (E.) fergusonii. 补充E. fergusonii在小鼠模型中改善了过敏症状,这表明了对儿科AR的潜在治疗方法.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 儿科过敏症儿童过敏症
背景情况:
- 肠道微生物群在儿童过敏性鼻炎 (AR) 中的作用尚不清楚,特别是在过敏原暴露方面.
- 这项研究调查了小儿AR中的肠道微生物群和室内灰尘虫 (HDM) 特定IgE之间的联系.
研究的目的:
- 确定肠道微生物群组成与AR儿童的HDM特异性IgE反应之间的相关性.
- 在过敏性鼻炎的小鼠模型中评估Escherichia (E.) fergusonii的治疗潜力.
主要方法:
- 便元基因组射门测序对60名患有HDM-AR的儿童和48名健康对照 (HC) 的微生物群进行了比较.
- 评估了口服E. fergusonii在对卵素和HDM敏感的小鼠的影响,监测过敏症状,免疫细胞透和T细胞平衡.
主要成果:
- 与HC相比,患有HDM-AR的儿童表现出肠道微生物多样性的减少和E. fergusonii丰度的降低.
- E. fergusonii的丰富度与HDM特定的IgE水平有负相关性.
- 在小鼠中,口服E. fergusonii可降低过敏症状,鼻炎和调节T细胞反应,表明向非过敏特征的转变.
结论:
- 肠道微生物群的变化,特别是E. fergusonii的减少,与儿童时期的HDM-AR相关.
- 费尔古索尼 (E. fergusonii) 显示出作为治疗儿科HDM-AR的潜在治疗剂的前景.
- 准肠道微生物群是治疗HDM-AR的一种新策略.
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