加斯德明D通过调节IL-1β释放和肠道微生物群组成,促进肠道瘤的发展
Hanchao Gao1, Weilong Li2, Shi Xu3
1Department of Nephrology, Shenzhen Longhua District Key Laboratory for Diagnosis and Treatment of Chronic Kidney Disease, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, 518110, China. hcgao@foxmail.com.
加斯德明D (GSDMD) 通过增加IL-1β和Kynurenine (Kyn) 的产生促进结直肠癌 (CRC). 减少GSDMD抑制了瘤生长,突出了其在肠道微生物群-宿主轴上的作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 肠道微生物群与宿主之间的相互作用对健康至关重要,而失生症有助于诸如结肠直肠癌 (CRC) 这样的疾病.
- 将肠道微生物群和宿主相互作用与CRC发展联系在一起的精确机制尚未完全理解.
- 加斯德明D (GSDMD) 是一种炎症酶效应因子,涉及到细胞灭.
研究的目的:
- 为了调查Gasdermin D (GSDMD) 在自发性结直肠癌 (CRC) 的发展中的作用.
- 阐明GSDMD影响CRC肠道微生物群组成和宿主代谢的机制.
主要方法:
- 在人类和小鼠肠道瘤样本中分析GSDMD表达.
- 使用Apcmin/+Gsdmd-/-小鼠,一个自发的CRC模型,来评估瘤的发展.
- 测量IL-1β水平,进行16srRNA测序以分析肠道微生物群,并量化Kynurenine (Kyn) 水平.
主要成果:
- 在肠道瘤中,GSDMD被上调;在Apc小鼠中,GSDMD缺乏明显抑制了瘤的发展.
- Apcmin/+Gsdmd-/-小鼠显示肠道IL-1β释放减少,乳杆菌丰度增加.
- 在Apcmin/+Gsdmd-/-小鼠中观察到减少的Kynurenine (Kyn) 水平,Kyn与乳酸菌的丰度相反相关.
结论:
- 通过增加IL-1β释放和Kynurenine (Kyn) 生产,GSDMD促进了自发的CRC发展.
- 研究结果表明,GSDMD,肠道微生物群,托/Kynurenine通路和CRC之间存在联系.
- 在结直肠癌的进展中,GSDMD成为潜在的治疗点.
更多相关视频
07:34Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
相关概念视频
Role Of Notch Signalling In Intestinal Stem Cell Renewal
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Renewal of Intestinal Stem Cells
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
What is Monogastric Digestion?
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
