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在神经退行性疾病中疑似伪布鲁巴影响
Maureen K O'Connor1,2,3,4, Brandon Frank3,4,5, Renée DeCaro5
1Neuropsychology Service, Bedford VA Healthcare System, Bedford, Massachusetts, USA.
International journal of geriatric psychiatry
|October 21, 2024
概括
在阿尔茨海默病 (AD) 患者中,伪obulbar影响 (PBA) 与更好的记忆回忆和识别有关. 了解PBA可能有助于在神经退行性疾病中早期识别和治疗AD.
科学领域:
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
- 精神病学是一个精神病学.
背景情况:
- 伪布尔巴影响 (PBA) 的特点是不自发的情绪表达.
- 在神经退行性疾病中经常观察到PBA,但它与认知功能和阿尔茨海默病 (AD) 等特定诊断的关联需要进一步调查.
- 早期发现PBA可能有助于了解疾病的进展和治疗.
研究的目的:
- 探索疑似PBA,临床诊断,认知表现和老年痴呆症评估的情绪之间的关系.
- 确定阿尔茨海默病和其他神经认知障碍患者中PBA的患病率.
- 为了比较疑似PBA和没有PBA的患者之间的认知测试表现.
主要方法:
- 网络建模被用来分析神经心理测试,评分尺度和神经学研究中心-劳动力尺度 (CNS-LS) 之间的关联在311名门诊患者中.
- 包括怀疑AD (n=133) 和其他神经认知诊断 (n=178) 的患者.
- 倾向性得分匹配和贝叶斯模型被用来比较怀疑PBA (CNS-LS ≥13) 和没有PBA的患者之间的认知表现,控制共变量.
主要成果:
- 疑似PBA的患病率在AD中约为44.4%,在其他痴呆症中类似.
- 在网络模型中,较高的CNS-LS分数与增加的焦虑和改进的词汇列表回忆相关.
- 与没有PBA的AD患者相比,怀疑PBA的AD患者表现出增强的单词列表回忆和更少的虚假识别错误.
结论:
- 在AD患者中疑似PBA与更好的记忆回忆和识别有关,这表明情绪失调可能是早期AD指标.
- 这些发现凸显了PBA作为AD早期征兆的潜力,特别是当记忆力下降不那么明显时.
- 对神经退行性疾病中PBA患病率和精神伴随性疾病的进一步研究对于及时诊断和干预至关重要.
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