在临床干预中对胃炎作为免疫相关的不良事件进行系统审查
Fei Su1,2, Wen-Xuan Fan1,2, Yan Zhang2,3
1Department of Graduate School, Shanxi Medical University, Taiyuan, Shanxi, China.
Human vaccines & immunotherapeutics
|October 22, 2024
概括
免疫检查点抑制剂 (ICI) 可以引起与免疫相关的胃炎,这种情况报告有限. 本综述强调了常见的症状,有效的皮质类固醇治疗,以及这种ICI副作用的诊断方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI) 是重要的癌症疗法,但与免疫相关的不良事件 (irAEs) 是一个问题.
- 与ICI相关的免疫性胃炎很少被报告,这给诊断和管理带来了挑战.
- 目前的临床指南缺乏免疫相关胃炎的标准化标准.
研究的目的:
- 系统地审查接受ICI的患者免疫相关胃炎的文献.
- 整合关于临床表现,诊断方法和治疗结果的数据.
- 为了告知临床实践关于这个特定的irAE.
主要方法:
- 对Medline,Web of Science和Embase数据库进行了系统审查.
- 包括2017年至2023年12月31日出版的文章.
- 分析了31篇涉及258名患者的文章的数据.
主要成果:
- 常见的临床表现包括表胃疼痛 (53.1%) 和粘膜红斑 (56.1%).
- 组织病理学发现经常显示淋巴细胞透 (48.6%).
- 皮质类固醇治疗被广泛使用 (94.7%),改善率高 (86.7%).
- 80%的病例可以通过内镜和病理学来诊断;剩余20%需要PET-CT.
结论:
- 与免疫相关的胃炎具有独特的临床和病理特征,需要特定的管理策略.
- 皮质类固醇治疗在治疗ICI诱导的胃炎方面表现出显著的疗效.
- 准确及时诊断,利用内镜,病理学,有时是PET-CT,对于有效的患者管理至关重要.
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