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Updated: Jun 9, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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通过局部特异性抗体与曼诺6-酸盐甘氨酸结合的向蛋白质降解

Kaori Mukai1, Robert Cost2, Xin Sheen Zhang3

  • 1Immunology & Inflammation Research, Sanofi, Cambridge, MA, USA.

mAbs
|October 22, 2024
PubMed
概括

我们开发了一种新型的抗体结合方法,用于创建色素向化马 (LYTACs),用于向蛋白质降解. 这种方法有效地针对TNF等细胞外蛋白进行 lysosomal 降解,从而提供了新的治疗可能性.

关键词:
在CI-MPR中,在LYTAC中,我们可以使用LYTAC在M6P中,M6P是M6P.合 bisM6P 的抗体.蛋白质降解 蛋白质降解

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