瘤细胞上腺瘤:临床特征和长期结果
Alaa Sada1,2, Josiane Joseph3, Reem Alsibai2
1Department of Surgery, Mayo Clinic, Rochester, MN, USA.
The American surgeon
|October 22, 2024
概括
囊性上腺瘤很少见,但可能是恶性或具有恶性潜力. 对于不确定的病例,仔细的随访至关重要,因为Ki67可以预测复发.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 囊性上腺瘤,以≥90%的囊性细胞为特征,并不常见.
- 上腺瘤中瘤细胞变化的临床意义尚未明确.
研究的目的:
- 评估纯瘤细胞性上腺瘤的临床行为和结果.
- 确定这些罕见瘤的恶性潜力和复发率.
主要方法:
- 对33名因纯瘤细胞瘤而接受上腺切除术的成年患者 (1997-2022) 的回顾性分析.
- 使用林-韦斯-比塞格利亚系统 (良性,恶性,潜在不确定性) 分类的新生体.
- 统计分析包括费舍尔精确,克鲁斯卡尔-瓦利斯和卡普兰-梅尔方法; Ki67扩散指数评估.
主要成果:
- 24%是良性的,36%是恶性的,39%是不确定的恶性潜力.
- 在良性瘤中没有复发;在恶性瘤中50%的复发.
- 不确定的潜在瘤以转移性上腺皮癌的形式复发;较高的Ki67%与复发相关.
结论:
- 眼细胞性上腺瘤虽然很少见,但具有显著的恶性瘤或潜在恶性瘤风险.
- 由于复发风险,对未确定恶性潜在的上腺瘤进行密切的随访至关重要.
- 基67指数是这些瘤中复发的有价值预测指标,应定期获得.
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