性功能障碍男性的丸激素替代:柯克兰系统性审查的缩写版本
Hunju Lee1, Eu Chang Hwang2,3, Cheol Kyu Oh4
1Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
The world journal of men's health
|October 22, 2024
概括
替代疗法 (TRT) 没有显著改善性功能障碍男性的勃起功能或性生活质量. 该研究发现,TRT与安慰剂相比,没有影响心血管死亡率或不良事件.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 临床试验 临床试验
背景情况:
- 性功能障碍影响了大量的男性.
- 替代疗法 (TRT) 是一种潜在的治疗选择.
- 关于TRT在性功能障碍中的有效性和安全性的证据仍在争论中.
研究的目的:
- 评估TRT与安慰剂或男性性功能障碍的其他治疗方法的比较有效性.
- 评估TRT对勃起功能,性生活质量和心血管结果的影响.
- 分析TRT与不良事件和泌尿症状的关联.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析.
- 进行了全面的文献搜索,截至2023年8月29日,没有语言或出版状况限制.
- 纳入标准集中在评估性功能障碍男性TRT的RCT上.
主要成果:
- 分析了43个RCT,涉及11,419名参与者.
- 与安慰剂相比,TRT在勃起功能 (IIEF-EF) 中几乎没有差异 (MD: 2.37,95% CI: 1.67至3.08).
- 在性生活质量 (老年男性症状量表),心血管死亡率或因不良事件,前列腺问题或下泌尿道症状而导致的治疗中止方面没有观察到显著差异.
结论:
- 在性功能障碍的男性中,TRT似乎对勃起功能或性生活质量没有显著的益处.
- 与安慰剂相比,TRT没有增加心血管死亡或泌尿系统不良事件的风险.
- 目前的证据表明,TRT对该人群的研究结果的优势有限.
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