在美国的献血者中,输血可传播的共感染
Galen Conti1, Edward P Notari1, Roger Y Dodd1
1American Red Cross, Rockville, Maryland, USA.
Transfusion
|October 22, 2024
概括
同感染,定义为多种输血传染性感染 (TTIs) 在献血者,是不常见的,但与特定的人口和感染,如艾滋病毒,HBV,HCV和梅毒.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 血液安全 血液安全
背景情况:
- 输血传染性感染 (TTIs) 是献血中已知的风险.
- 在美国献血者中,单次TTI的患病率已得到证实.
- 本研究侧重于多个TTI (共感染) 的捐赠者的患病率和特征.
研究的目的:
- 估计两种或多种TTI (共感染) 的献血者的患病率.
- 描述具有共感染的捐赠者的人口统计数据.
- 为了确定特定的TTI共感染组合之间的关联.
主要方法:
- 利用了输血传染性感染监测系统 (2020年10月-2023年9月) 的数据.
- 对于TTI共感染组合的每百万捐献 (pmd) 的计算流行率.
- 使用后勤回归来估计共感染的几率,定义共识阳性 (CP) 和活跃梅毒感染 (ASI).
主要成果:
- 在大约2200万次捐赠中,确定了212例共感染 (9.7分钟/天).
- 共感染约占所有TTI阳性捐赠的2%.
- 患病率因TTI组合而异,艾滋病毒CP和梅毒CP为每天4.3人;发现艾滋病毒CP和ASI有显著的关联 (395倍更有可能).
结论:
- 美国献血者之间的共同感染相对较少.
- 在HIV,HBV,HCV和梅毒感染之间观察到特定的关联.
- 了解这些共感染模式对于血液安全监测至关重要.
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