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Updated: Jun 9, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

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扩散性质瘤中的Siglec-15表达及其与MRI形态特征及其明显扩散系数的相关性.

Quan Chen¹, Chunhua Wang¹, Yingqian Geng²

¹Department of Neurosurgery, Fujian Medical University Union Hospital, Fuzhou, PR China.

Acta radiologica (Stockholm, Sweden : 1987)

|October 22, 2024

概括

酸结合性免疫球蛋白类讲素15 (Siglec-15) 存在于扩散性质瘤中,与瘤特征相关. 积极的Siglec-15表达与较小的瘤大小和较高的明显扩散系数 (ADC) 值有关.

关键词:

酸结合性免疫球蛋白类学菌素15 酸结合性免疫球菌素15 看似的扩散系数.质瘤质瘤是一种异酸盐脱基酶是什么磁共振成像技术的使用

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科学领域:

神经瘤学神经瘤学
免疫学免疫学免疫学
放射学放射学是一门学科.

背景情况:

酸结合性免疫球蛋白类似的lectin 15 (Siglec-15) 与瘤免疫逃避和生长有关.
了解扩散性质瘤中的Siglec-15表达对于诊断和预后至关重要.

研究的目的:

为了研究Siglec-15在扩散性质瘤中的表达.
为了将Siglec-15表达与瘤磁共振成像 (MRI) 功能相关联.

主要方法:

分析了57名质瘤患者的MRI数据,包括形态学和明显扩散系数 (ADC) 值.
阳性和阴性Siglec-15表达的患者之间的MRI特征比较.
使用接收器操作特征 (ROC) 曲线来评估诊断性能.

主要成果:

西格莱克-15在周围瘤免疫细胞,特别是巨细胞中表达,阳性率为35.09%.
积极的Siglec-15表达与较小的瘤直径和较高的ADC值相关.
综合直径和ADC实现了0.762的AUC用于诊断评估.

结论:

西格莱克-15在扩散性质瘤的瘤微环境中表达.
西格莱克-15表达作为潜在的成像生物标志物,与瘤大小和ADC值相关.
这些发现表明Siglec-15在质瘤进展中的作用及其作为成像标记物的潜力.