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对鱼类中 parabens 的毒性潜力的系统审查
Asok K Dasmahapatra1, Joydeep Chatterjee2, Paul B Tchounwou3
1Department of BioMolecular Science, Environmental Toxicology Division, University of Mississippi, Oxford, MS, United States.
Frontiers in toxicology
|October 22, 2024
概括
化品中的素威胁着水生生物. 研究表明,这些化学物质破坏鱼的内分泌系统,影响繁殖和发育,更长的链条更有毒. 环境的持续存在对人类构成风险.
科学领域:
- 环境毒理学环境毒理学
- 水生生态毒理学 水生生态毒理学
- 内分泌干扰 干扰内分泌系统
背景情况:
- 烯是化品和个人护理产品 (PCP) 中广泛使用的抗微生物防腐剂.
- 它们的物理化学性质有利于广泛使用,但环境释放对水生生态系统构成风险.
- 之前的研究突出了类污染对鱼类的潜在威胁.
研究的目的:
- 审查现有的关于常见 parabens 对特定鱼类物种影响的文献.
- 在生态毒理学研究中确定研究最多的化合物和鱼类.
- 评估鱼类中的类的毒性和内分泌干扰潜力.
主要方法:
- 在PubMed中使用关键词"parabens"和"fish"进行电子文献搜索.
- 过结果包括四种常见的类甲 (甲,乙,,丁类甲) 和六种主要的鱼类物种.
- 分析了48篇精选的文章,分析了类毒性,内分泌干扰和环境影响数据.
主要成果:
- 斑马鱼 (Danio rerio) 和甲基是最常被研究的.
- 与链条较短的对应物相比,链条较长的帕拉本具有更高的毒性.
- 类化合物作为内分泌干扰剂,影响雌激素-雌激素-甲状腺-类固醇生成 (EATS) 途径,伴生体发育,并导致代际毒性.
- 暴露导致鱼类的行为变化和神经系统障碍.
结论:
- 素是鱼类中重要的内分泌干扰剂,影响生殖健康和发育.
- 毒性因烯结构而异,较长的链条更有害.
- 尽管有监管限制,但对的环境持久性引起了对水生动物和潜在的人类健康的关注.
相关概念视频
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Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
01:23Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...