全免疫炎症值与慢性阻塞性肺病之间的关联:来自NHANES 1999-2018年的数据
Shuhui Qiu1, Qi Jiang1, Yang Li1
1Department of Respiratory and Critical Care Medicine, First Hospital of Jilin University, Changchun, Jilin, China.
Frontiers in physiology
|October 22, 2024
概括
全免疫炎症值 (PIV) 与较高的慢性阻塞性肺病 (COPD) 患病率有关. 在COPD患者中,高和低的PIV水平与增加的死亡率相关,突出了PIV.
科学领域:
- 生物标志物和诊断方法
- 肺病学和呼吸系统医学
- 炎症和免疫学 炎症和免疫学
背景情况:
- 全免疫炎症值 (PIV) 是一种新兴的系统性免疫炎症状态的生物标志物.
- 在各种临床环境中确立了PIV的预测价值,但其在COPD中的作用尚不清楚.
研究的目的:
- 调查PIV和COPD患病率之间的关联.
- 检查PIV与COPD患者全因死亡率之间的关系.
主要方法:
- 利用了来自NHANES 1999-2018年28485名40岁以上的参与者的数据.
- 采用后勤和COX回归,卡普兰-梅尔曲线和受限立方线分析.
- 进行了子组和灵敏度分析,以评估共变效应和结果稳定性.
主要成果:
- 较高的PIV水平独立地与COPD患病率 (OR=1.67) 和所有原因死亡率 (HR=2.04) 的增加有关.
- 观察到非线性关系:COPD患病率在PIV超过值时增加 (Log10-PIV=2.24);死亡率与PIV值显示复杂的关联 (Log10-PIV=2.38).
- PIV与COPD患病率的关联受种族,吸烟状况和BMI的影响;死亡率关联在各子组中都很强大.
结论:
- 较高的PIV水平与较高的COPD患病率有关.
- 患有高或低PIV水平的COPD患者的全因死亡率增加.
- 需要进一步的大规模纵向研究来证实这些发现.
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