对辅助生殖技术的精子选择技术进行叙事审查
David K Charles1, Moritz J Lange1, Nicolas M Ortiz1
1Department of Urology, University of Virginia, Charlottesville, VA, USA.
Translational andrology and urology
|October 22, 2024
概括
精子选择技术,包括上游和密度梯度离心,对于提高体外受精 (IVF) 成功率至关重要. 虽然新技术充满希望,但目前的方法仍然是最有效的辅助生殖技术的结果.
科学领域:
- 生殖医学 生殖医学
- 辅助生殖技术 辅助生殖技术
- 精子生物学 精子生物学
背景情况:
- 在体外受精 (IVF) 与细胞内质精子注射 (ICSI) 被广泛使用,即使没有男性因子不孕症.
- 尽管技术进步,但IVF/ICSI的活产率停滞不前.
研究的目的:
- 审查目前在辅助生殖技术中精子选择科学的现状.
- 评估现有和新兴精子选择技术的有效性.
主要方法:
- 对1989年至2024年间发表的英语研究文章进行了全面的PubMed搜索.
- 审查的重点是报告关于辅助生殖技术中精子选择技术数据的研究.
主要成果:
- 尽管有众多的精子选择技术,但游起来和密度梯度离心是最常用的.
- 目前的试管婴儿/ICSI结果仍然停滞不前,没有一种技术能够证明其优于传统方法.
- 新兴技术如表观遗传学,精子生物标志物和人工智能显示出潜力,但需要进一步研究.
结论:
- 精子选择技术有望提高超越标准ICSI的生殖结果.
- 目前,没有一种方法能超越泳起来和密度离心法在精子制备中的有效性.
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