关于线粒体功能障碍和男性不孕不育的叙述性回顾
Zihang Mai1, Di Yang1, Dan Wang2
1Department of Urology, Shenzhen University General Hospital, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Translational andrology and urology
|October 22, 2024
概括
线粒体功能障碍通过影响能量生产和精子运动性,显著损害精子功能和男性生育能力. 了解这些机制是开发不孕症新诊断和治疗策略的关键.
科学领域:
- 生殖生物学 生殖生物学
- 线粒体医学 线粒体医学
- 男人不孕症研究研究
背景情况:
- 线粒体功能障碍是减少精子功能和男性不孕症的关键因素.
- 线粒体对于精子能量产生,反应性氧物种 (ROS) 控制,细胞亡调节和运动性至关重要.
- 线粒体结构,功能或完整性的改变会对男性生殖健康产生负面影响.
研究的目的:
- 为了澄清线粒体在男性生殖健康中的关键作用.
- 探索线粒体功能障碍与男性不孕症之间的联系.
- 审查针对线粒体的男性不孕症的当前和新兴治疗策略.
主要方法:
- 在PubMed,谷歌学者和其他数据库 (2014-2023) 的系统文献搜索.
- 对有关男性不孕症和线粒体功能障碍的相关文章进行查和总结.
- 分析精子质量,DNA损伤,氧化应激和线粒体生物能学之间的关系.
主要成果:
- 线粒体功能障碍直接影响精子的生命力,形态和容量.
- 精子运动性和男性不育性与线粒体结构和功能中断有关.
- 线粒体突变,缺失和SNP会影响精子生成和精子功能.
- 年龄,生活方式和环境因素影响线粒体功能和男性生育能力.
结论:
- 线粒体缺陷在男性不孕症中至关重要,影响精子功能和质量.
- 需要进一步研究,以了解不孕男性线粒体功能障碍的潜在机制.
- 本综述是了解男性不孕症和探索针对线粒体的治疗方法的资源.
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