通过调节肠道微生物群和短链脂肪酸,Elaeagnus angustifolia的果实可以缓解腹
Xiatiguli Abulizi1, Ming-Hui Shi1, Yue-Mei Jia2
1Xinjiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, 830011, China.
Heliyon
|October 22, 2024
概括
埃拉格努斯 (Elaeagnus angustifolia) 的果实通过调节肠道微生物群和增加短链脂肪酸 (SCFA) 来缓解腹. 这项研究阐明了抗腹机制,为其药用提供了洞察力.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 伊拉 (Elaeagnus angustifolia L.) 的果实是维吾尔人的传统药物,用于治疗各种疾病,包括腹.
- 对于E. angustifolia果的抗腹作用的确切机制尚不清楚.
- 了解肠道微生物群的作用对于阐明其治疗作用至关重要.
研究的目的:
- 为了研究Elaeagnus angustifolia水果的抗腹机制.
- 探索E. angustifolia果实对肠道微生物群组成和短链脂肪酸 (SCFA) 生产在腹小鼠模型中的影响.
主要方法:
- 在小鼠中使用Folium sennae诱导了腹模型.
- 评估了腹率,腹指数和结肠组织病理学 (血氧氨酸染色).
- 使用16S rRNA测序分析了肠道微生物群,并通过GC-Q-TOF-MS测量了SCFA度.
主要成果:
- 高剂量的E. angustifolia果实显著降低了腹率和指数 (p < 0.01).
- 施用E. angustifolia果实增加了肠道微生物群的多样性并改变了其结构.
- 在E. angustifolia水果治疗后,肠道中SCFA度升高.
结论:
- 埃拉格努斯 (Elaeagnus angustifolia) 果实通过调节肠道微生物群的组成和丰富性,有效地缓解腹.
- 增加SCFA水平有助于E. angustifolia果的抗腹作用.
- 这项研究提供了对E. angustifolia水果用于治疗腹的传统用途的机制性见解.
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