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在老鼠中,托克塞鲁丁对基托洛拉克诱导的胃的影响:与氧化应激的关系

Alaa Zouher Darkazally¹, Amirah Alnour², Shadi Homsi¹

¹Department of Pharmacology, Faculty of Pharmacy, Damascus University, Damascus, Syria.

|October 22, 2024

概括

托克塞鲁丁表现出抗氧化作用,减少氧化应激,改善大鼠的胃指数. 这项研究强调了其在预防NSAID诱导的胃方面的潜力.

科学领域:

药理学药理学是指药理学的学科.
胃肠病学胃肠病学
氧化压力研究研究氧化压力研究

背景情况:

非类固醇抗炎药物 (NSAIDs) 通常会导致胃.
自由基在NSAID诱导的胃发育中起着关键作用.
托克塞鲁丁具有抗氧化和抗炎性质,对其胃保护作用的研究有限.

研究的目的:

在大鼠模型中研究托克塞鲁丁对托洛拉克诱导的胃的预防作用.
在NSAID引起的胃损伤的背景下评估托克塞鲁丁的抗氧化活性.
评估托克塞鲁丁对胃炎和氧化应激标志物的影响.

主要方法:

二十九只老鼠被分为车辆,凯托洛拉克 (Keto),托克塞鲁丁 (150或200毫克/公斤) 和米索 (Miso) 组.
托克塞鲁丁和弥索普罗斯托尔在开托洛拉克之前1小时被口服.
测量了指数,胃炎症,铁酸反应物质 (TBARS) 水平和催化酶活性.

主要成果:

与凯托罗拉克相比,特洛克苏丁和米索普罗斯托尔都显著改善了的指数.
米索普罗斯托尔减少了胃炎症,而托克塞鲁丁没有显著的影响.
凯托洛拉克诱导的胃氧化应激减少了托克塞鲁丁和米索普罗斯托尔.

结论:

托克塞鲁丁表现出抗氧化作用,有助于预防基托洛拉克诱导的胃.
这项研究首次证实了托克塞鲁丁在缓解NSAID诱导的胃方面的抗氧化作用.
托克塞鲁丁显示出作为预防NSAID相关胃肠道副作用的潜在药物具有前途.

关键词:

胃潰瘍胃潰瘍胃潰瘍凯托洛拉克是什么意思凯托洛拉克氧化应激是一种氧化应激.这是一个Troxerutin.

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