热敏和响应pH值的感染性虫含胆汁凝具有长期的抗炎作用,用于性结肠炎
Jiaojiao Bai1, Yan Ding1, Mubarak Iminjan1,2
1College of Pharmacy, Xinjiang Medical University, Urumqi, 830017, China.
使用Quercus infectoria胆汁 (QIG) 的新型pH/热敏凝有效治疗小鼠的性结肠炎 (UC). 这种局部输送系统可以提高QIG在炎症部位的度,促进结肠的修复和减少炎症标志物.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 胃肠病学 胃肠病学
- 材料科学 材料科学 材料科学
背景情况:
- 急性性结肠炎 (UC) 带来了重大治疗挑战.
- 现有的UC药物输送系统存在局限性.
- 虫感染性胆汁 (QIG) 显示出潜在的治疗性质.
研究的目的:
- 开发一种pH/热敏的in situ凝输送系统,用于在UC治疗中进行QIG透水注射.
- 为了表征QIG-乙醇提取物pH/温度敏感凝 (QIG-pH-TSG).
- 在UC的小鼠模型中评估QIG-pH-TSG的治疗疗效.
主要方法:
- 使用DSC,SEM,风湿学和药物释放研究对QIG-pH-TSG的表征.
- 在LPS.激活的RAW 264.7细胞的体外抗炎试验.
- 使用UC小鼠进行体内研究,以评估治疗效果,结肠组织学和炎症标志物.
主要成果:
- 在生理条件下,QIG-pH-TSG表现出sol-gel过渡,增强结肠保留.
- 该凝通过调节细胞因子水平 (TNF-α,IL-6,IL-10) 来表现出显著的体外抗炎活性.
- 在体内研究显示,结肠损伤减少,结肠长度增加,炎症标志物 (IL-6,TNF-α,CRP) 减少,UC小鼠IL-10增加.
结论:
- 开发的QIG-pH-TSG是一种有效的现场输送系统,用于治疗UC.
- 这个系统增强了局部药物度,并促进了结肠粘膜的修复.
- QIG-pH-TSG为UC治疗提供了一个有希望的替代方案,克服了当前配方的局限性.
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