艾滋病毒治疗中的药物相关问题 治疗失败
Mohd Farizh Che Pa1,2, Ng Tiang Koi3, Arisah Misnan4
1Center of Quality Medicine Management, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, MYS.
Cureus
|October 22, 2024
概括
与药物相关的问题 (DRPs) 在人类免疫缺陷病毒 (HIV) 治疗中很常见,严重影响治疗的有效性和安全性. 识别这些DRP对于改善患者在艾滋病毒治疗中的结果至关重要.
科学领域:
- 药物监督 药物监督 药物监督
- 临床药房 临床药房
- 传染性疾病 传染性疾病
背景情况:
- 抗逆转录病毒疗法 (ART) 对于控制人类免疫缺陷病毒 (HIV) 是必不可少的,减少了相关的发病率和死亡率.
- 了解与毒品有关的问题 (DRP) 及其原因对于解决艾滋病毒治疗失败至关重要.
- 之前的研究还没有完全阐明导致艾滋病毒患者治疗失败的特定DRP及其起源.
研究的目的:
- 确定与人类免疫缺陷病毒 (HIV) 患者治疗失败相关的与药物相关问题的类型和原因.
- 调查DRP与艾滋病毒感染者队列治疗结果之间的关系.
- 确定与患者相关的特定因素和药物选择问题,这些因素有助于艾滋病毒治疗中的DRP.
主要方法:
- 这是一项多中心的回顾性队列研究,涉及355名患者 (263例治疗成功,92例治疗失败).
- 从医疗记录中提取的数据,包括进展记录,实验室结果和ART治疗方案.
- 欧洲药品护理网络 (PCNE) 分类系统V9.1被用于识别和分类DRP及其原因.
主要成果:
- 几乎所有患者 (99.7%) 经历了至少一个DRP,发现了811个问题和1605个原因.
- 与治疗成功的患者相比,艾滋病毒治疗失败的患者患有DRP的发病率更高 (每患者5.77),治疗成功的患者 (每患者4.08).
- 治疗有效性 (P1) 和治疗安全性 (P2) 是失败组中最常见的问题领域,患者相关因素 (C7) 是主要原因.
结论:
- 与药物相关的问题 (DRPs) 在人类免疫缺陷病毒 (HIV) 治疗失败的患者中非常普遍.
- 药物治疗方案显著影响治疗的有效性和安全性,强调了需要积极的药物护理.
- 与患者相关的因素和药物选择问题是HIV治疗中DRP的关键因素,需要有针对性的干预措施.
更多相关视频
相关概念视频
Retrovirus Life Cycles
45.7K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.7K
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Sexually Transmitted Infections
286
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
286
Immunodeficiency Diseases
911
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
911
Hemodialysis II: Procedure and Complications
1
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
1
Drug Therapy
39
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
39


