在SARS-CoV-2感染和急性缺血性结肠炎之间存在关联
Yanping Wu1, Yueqin Zheng1, Sumei Sha1
1Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, People's Republic of China.
Journal of inflammation research
|October 22, 2024
概括
COVID-19可能会导致罕见的严重缺血性结肠炎. 这项研究发现,像腹痛和血症这样的症状在感染后两周内出现,并且自我限制,没有观察到慢性变化.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- COVID-19 是一种具有多样性临床表现的全球流行病.
- 缺血性结肠炎是一种罕见但严重的胃肠道并发症.
- 住院COVID-19患者的一小部分患者表现出暗示缺血性结肠炎的内镜特征.
研究的目的:
- 研究COVID-19患者缺血性结肠炎的临床表现,治疗和结果.
- 详细介绍这些患者的结肠镜和组织学发现.
- 了解COVID-19感染和胃肠道症状之间的时间关系.
主要方法:
- 一项前性研究涉及12名疑似患有与COVID-19相关的缺血性结肠炎的患者,涉及四个中心.
- 通过结肠镜检查和活检证实了诊断.
- 在电子病历中搜索相关数据.
- 通过电话采访进行了12个月的随访.
主要成果:
- 该研究包括12名患者 (3名男性,9名女性;年龄在33-76岁之间).
- 在COVID-19后的2周内 (平均5.5天) 发生了腹痛和血.
- 下降结肠受影响最大 (83.33%).
- 结肠镜检查显示了扩散的粘膜炎症;活检显示了密室缩和间歇性出血.
- 所有病例都是自我限制的,在12个月后没有慢性后果.
结论:
- SARS-CoV-2 感染可以诱导过渡性急性结肠缺血.
- 症状在感染后两周内表现出来,通常是自我限制的.
- 与COVID-19相关的缺血性结肠炎似乎不会导致慢性胃肠道问题.
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