在COVID-19大流行期间,社会基因组学,认知和福祉
James R Bateman1,2,3,4, Sudarshan Krishnamurthy3, Ellen E Quillen5
1Department of Neurology Wake Forest University School of Medicine Winston-Salem North Carolina USA.
Alzheimer's & dementia (Amsterdam, Netherlands)
|October 22, 2024
概括
尤达蒙的幸福感与正常认知和轻度认知障碍中的逆境 (CTRA) 基因表达的低保守转录反应有关. 应对策略对CTRA基因表达的影响因认知状态而异.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 认知神经科学 认知神经科学
- 遗传学 遗传学 是一个
背景情况:
- 不良的心理社会暴露会增加促炎性基因表达 (CTRA).
- CTRA在认知障碍中的作用尚未得到充分研究,但可能会影响晚年认知衰退.
- 了解认知衰退中的CTRA对于开发有针对性的干预措施至关重要.
研究的目的:
- 研究心理社会因素 (压力,孤独,幸福感) 与CTRA基因表达之间的关系.
- 检查认知状态 (正常认知与轻度认知障碍) 如何影响这些关联.
- 探索COVID-19对CTRA基因表达的影响.
主要方法:
- 利用混合效应线性模型来分析关联.
- 评估感知到的压力,孤独感和eudaimonic幸福感.
- 与心理社会变量和认知状态相关的量化CTRA基因表达.
主要成果:
- 在正常认知和轻度认知障碍组中,Eudaimonic幸福感与CTRA基因表达呈反向关联.
- 认知组之间的应对策略有所不同,对CTRA基因表达有不同的影响.
- 在这个队列中,孤独没有显著影响CTRA基因表达.
结论:
- 欧戴蒙的幸福感是压力的重要相关因子,无论认知状态如何,包括轻度认知障碍.
- 认知能力下降可能会减轻应对策略对CTRA基因表达的影响.
- 这些发现突出了心理社会福祉,基因表达和认知健康之间的相互作用.
相关概念视频
01:28Human Genetics
536
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
536
02:02Genomics
36.1K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.1K
01:30Stress and Mental Health
78
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
78
01:20Psychological Responses to Stress
45
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
45
01:18Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K
01:30Social Cognitive Perspective on Personality
499
Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
499