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对清细胞癌晚期复发的预后因素的评估:一项机构研究

Diana Voskuil-Galoş¹, Tudor Călinici², Andra Piciu^1,3

¹Department of Medical Oncology, The Oncology Institute Prof. Dr. Ion Chiricuţă, Cluj-Napoca, Romania.

Frontiers in oncology

|October 22, 2024

概括

非转移性细胞癌 (nmRCC) 的晚期复发是常见的. 预后因素如IMDC得分和Fuhrman等级影响生存率,表明需要在手术后对患者进行延长的随访.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

一部分患有非转移性细胞癌 (nmRCC) 的患者经历了晚期复发,定义为经过切除术5年以上的转移性复发.
了解这些晚期复发的患病率和预后因素对于优化患者管理至关重要.

研究的目的:

评估罗马尼亚患者晚期复发的发病率,这些患者经过切除术后患有nmRCC.
确定临床病理学特征,作为晚期复发RCC的预后指标.

主要方法:

一项回顾性,单中心的观察性研究分析了51名患有清晰细胞nmRCC组织学的患者,这些患者接受了治疗性意图手术.
收集的数据包括无病生存率 (DFS),总生存率 (OS) 和与预后因素的相关性,如IMDC得分,NLR,瘤大小和Fuhrman核等级.

主要成果:

51%的患者复发,其中42%的患者在60个月后复发.
DFS与IMDC得分,中性粒细胞与淋巴细胞比率 (NLR),瘤大小和Fuhrman核等级有显著的相关性.
整体存活率 (OS) 与IMDC得分和Fuhrman核等级相关.

结论:

局部RCC的晚期复发并不罕见,在初级瘤手术后需要延长的随访间隔.
特定的生物标志物,包括IMDC评分和Fuhrman核等级,是预测RCC患者生存结果的有价值的预后因素.

关键词:

清细胞癌 (ccRCC) 是一种中性粒细胞与淋巴细胞的比率.血小板与淋巴细胞的比率.复发性复发性复发性手术手术手术手术手术手术手术

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