在Lu-PSMA-617治疗期间发生的转移性淋巴结压缩引起的急性胰腺炎和胆道阻塞:一个病例报告
Gokce Belge Bilgin1, Patrick J Navin1, Derek R Johnson1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States.
Frontiers in oncology
|October 22, 2024
概括
177PSMA疗法是转移性割抵抗性前列腺癌的有希望的治疗方法. 在患有周胰腺淋巴结转移的患者接受[177Lu]Lu-PSMA-617治疗后,观察到一种罕见的急性胰腺炎病例.
科学领域:
- 在瘤学瘤学.
- 核医学是一种核医学.
- 放射性药物疗法是一种放射性药物疗法.
背景情况:
- 放射性治疗,包括-177 PSMA ([177Lu]Lu-PSMA-617),代表了癌症治疗的进步.
- 临床试验和多中心研究已经确定了[177Lu]Lu-PSMA-617在转移性割抵抗性前列腺癌 (mCRPC) 的安全性和有效性.
- 越来越多地使用这些疗法,需要记录罕见的临床事件.
研究的目的:
- 报告在[177Lu]Lu-PSMA-617治疗期间观察到的独特临床表现.
- 要突出与这种治疗方式相关的潜在罕见不良事件.
主要方法:
- 病例报告详细介绍了一名患有mCRPC和周围胰腺淋巴结转移的患者.
- 在[177Lu]Lu-PSMA-617注射后观察和记录临床事件.
主要成果:
- 患者在接受[177Lu]Lu-PSMA-617治疗后发生了急性胰腺炎.
- 胰腺炎发生在周围胰腺淋巴结转移的背景下.
结论:
- 急性胰腺炎是[177Lu]Lu-PSMA-617治疗的一个罕见但潜在的并发症.
- 对这种罕见的不良事件的认识对于临床医生管理接受放射性连接体治疗的mCRPC患者至关重要,特别是那些具有相关淋巴结参与的患者.
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