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抗高血压药物和哈西莫托甲状腺炎之间的因果关系:一种药物向的门德尔式随机化研究
Bing Cui1, Aqin Chen1, Chengcheng Xu2
1Department of Blood Transfusion, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, ;China.
Frontiers in endocrinology
|October 22, 2024
概括
通道阻断剂 (CCB) 和利尿剂可能会降低哈希莫托甲状腺炎 (HT) 的风险. 这项研究使用了药物标的门德尔随机化方法来调查抗高血压药物对HT敏感性的影响.
科学领域:
- 药物基因组学 药物基因组学
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
背景情况:
- 新出现的证据表明,高血压,自身免疫性疾病和哈西莫托甲状腺炎 (HT) 之间存在联系.
- 抗高血压药物对HT风险的特定影响仍然在很大程度上未被描述.
- 了解这些关联对于管理并发病状况至关重要.
研究的目的:
- 研究九种类型的抗高血压药物对哈西莫托甲状腺炎 (HT) 易感性的长期影响.
- 通过药物向的门德尔随机化方法,探索欧洲和亚洲人群之间的这些关联.
主要方法:
- 利用药物标的门德尔随机化方法来评估抗高血压药物类对HT风险的影响.
- 雇佣与药物标和心压血压 (SBP) 相关的遗传变异来模仿药物效应.
- 纳入了欧洲和亚洲队列中SBP和HT风险的全基因组关联研究数据,并进行了eQTL分析以进行补充验证.
主要成果:
- 通道阻断剂 (CCB) 在欧洲和亚洲人群中显示出与降低HT风险的显著关联.
- 循环利尿剂和 thiazide 利尿剂显示出与降低 HT 风险的显著关联,仅在欧洲人口中.
- 当表达量性特征位点 (eQTLs) 用于表示药物向基因效应时,结果是一致的.
结论:
- 通道阻断剂 (CCB) 和某些利尿剂可能在不同人群中提供对哈西莫托甲状腺炎 (HT) 的保护作用.
- 这些发现表明,在HT预防策略中,抗高血压药物可能会被重新使用.
- 需要进一步的临床研究来证实这些药物类别在预防HT方面的治疗效用.
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