ViCE:一种自动化和定量化的程序,用于评估肠道组织形态
Jeffrey La1, Krishnan Raghunathan1, Jocelyn A Silvester1,2,3
1Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, United States of America.
Journal of pathology informatics
|October 22, 2024
概括
一个新的软件,ViCE (Villus Crypt Evaluator),自动量化肠道的高度与密室深度比 (Vh:Cd). 该工具提供了一种可复制和有效的方法,用于在临床实践中评估肠道肠道病变,如乳病.
科学领域:
- 组织病理学 组织病理学
- 计算生物学 计算生物学
- 胃肠病学 胃肠病学
背景情况:
- 肠道小和密室形成复杂的组织形态.
- 维卢斯高度至密室深度比 (Vh:Cd) 量化了肠道肠道病变的严重程度.
- 手动Vh:Cd测量耗时,限制了临床应用.
研究的目的:
- 开发一个自动化的软件,ViCE (Villus Crypt Evaluator),用于量化Vh:Cd.
- 为肠道活检中组织学参数评估提供一个用户友好的工具.
主要方法:
- ViCE使用数学形态运算.
- 该软件是规模和染色不可知.
- 它评估组织的方向,确定几何结构,并测量关键参数.
主要成果:
- ViCE自动量化Vh:Cd在血素和色素染色肠道活检中.
- 输出测量结果与数据集的手动量化结果一致.
结论:
- ViCE的数学形态方法是强大的和可重复的.
- ViCE可以适应测量其他组织的形态特征.
- 自动化Vh:Cd量化可以提高肠道疾病的临床实践.
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