结合疗法与单疗法的有效性在口服平斑:一项随机临床试验
Rocio Rodriguez-Galvez1, Asta Tvarijonaviciute2, Camila Peres-Rubio2
1Faculty of Medicine and Odontology, Hospital Morales Meseguer, Murcia, Spain.
Oral diseases
|October 22, 2024
概括
局部使用的三氨乙化物 (TA) 含有或不含氨酸 (HA) 显著改善了口腔平坦 (OLP) 症状. 在所有治疗组中,唾液氧化应激标志物保持不变.
科学领域:
- 口服药是一种口服药.
- 皮肤病学 皮肤病学
- 生物化学 生物化学
背景情况:
- 口腔平坦 (OLP) 是一种慢性炎症状况,影响口腔粘膜.
- 目前的治疗方法旨在控制症状并改善生活质量.
- 氧化应激在OLP病原和治疗反应中的作用需要进一步研究.
研究的目的:
- 为了比较三氨烯酸乙化物 (TA) 加氨酸 (HA) 与单一治疗对症状性OLP的疗效.
- 评估这些治疗对唾液氧化应激生物标志物的影响.
主要方法:
- 一项随机,双盲,单中心的研究,涉及60名OLP患者.
- 三个治疗组:TA + HA,单独的TA和单独的HA.
- 使用Thongprasom尺度,OHIP-14和VAS评估有效性;分析了唾液生物标志物 (SOD,GSH,TAC).
主要成果:
- 所有治疗组都显示了OLP症状的显著改善 (Thongprasom尺度,VAS,OHIP-14).
- 治疗效应在随访期间持续存在.
- 在任何组中都没有观察到唾液氧化应激生物标志物 (SOD,GSH,TAC) 的显著变化.
结论:
- 局部TA,有或没有HA,是有效的管理症状的OLP.
- 氨酸可能提供辅助益处或作为单一疗法有效.
- 目前的治疗方法没有显著改变OLP患者的唾液氧化应激水平.
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