循环蛋白与亡过程和糖尿病中末期病的快速发展有关
Katsuhito Ihara1,2,3, Eiichiro Satake1,2, Parker C Wilson4,5
1Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA.
JCI insight
|October 22, 2024
概括
高水平的特定循环蛋白质,特别是那些参与细胞亡和TNF受体信号传递的蛋白质,可以预测糖尿病患者患末期病 (ESKD) 的风险.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 腎臟病學 (nephrology) 是一種醫學.
- 分子生物学分子生物学
背景情况:
- 与末期病 (ESKD) 风险相关的循环蛋白质缺乏明确的起源和生物途径关联.
- 了解这些蛋白质来源对于识别糖尿病病中的疾病机制至关重要.
研究的目的:
- 在糖尿病患者中识别与ESKD风险相关的循环蛋白质.
- 研究这些蛋白质的生物通路和细胞起源.
- 使用蛋白质生物标志物开发ESKD风险的预测模型.
主要方法:
- 奥林克蛋白质组学平台用于测量399名糖尿病患者的455种血蛋白.
- 纵向跟踪 (7-15年) 来追踪ESKD的发展 (n=143).
- 在外围白细胞 (WBC) 和脏活检的单核RNA-Seq中进行基因表达分析.
主要成果:
- 46种与ESKD风险相关的循环蛋白 (P < 1 × 10-5).
- 20种蛋白质丰富了亡/TNF受体信号通路;亡得分预测了ESKD风险.
- 这些蛋白质的基因在受伤的脏靠近管细胞中表达过多,而不是白细胞.
结论:
- 循环蛋白质的升高,特别是那些表明细胞亡和TNF受体信号的蛋白质,可能来自受伤的细胞.
- 这些蛋白质生物标志物,特别是亡评分,可以预测糖尿病患者的ESKD发展.
- 研究结果强调,脏是ESKD风险循环生物标志物的来源.
相关概念视频
01:20Renal Corpuscle
1.7K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.7K
01:27Dialysis
272
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
272
01:24Nephrotic Syndrome I : Introduction
1
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1
01:10Nephrons
2.2K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
01:28Kidney Transplant I: Introduction
1
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
1
01:24Nephrotic Syndrome III : Nursing Management
1
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
1