患有后急性COVID-19症状 (PACS) 和长期COVID的患者的表观遗传变化:系统性审查
Madhura Shekhar Patil1, Emma Richter1, Lara Fanning1
1Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
Expert reviews in molecular medicine
|October 22, 2024
概括
表观遗传学研究提供了对后急性COVID-19症状 (PACS) 和长期COVID的见解. 虽然是初步的,但这些证据表明有针对性治疗和理解复杂,异质症状的潜力.
科学领域:
- * 分子生物学和表观遗传学.
- * 传染病和病毒后综合征.
- * 基因组学和个性化医学.
背景情况:
- * 后急性COVID-19症状 (PACS),或长期COVID,影响高达30%的SARS-CoV-2感染个体,呈现超过100种异质症状.
- *了解潜在的病理生理学和个人之间的差异对于开发有效的,针对患者的治疗方法至关重要.
- *表观遗传机制正在越来越多地被探索,以了解它们在各种健康状况中的潜在作用,包括长期COVID.
研究的目的:
- *系统地审查和总结现有的关于后急性COVID-19症状 (PACS) 和长期COVID中的表观遗传机制的文献.
- * 确定可能导致长期COVID病理生理学和异质性的表观遗传因素.
- * 评估目前的研究状况,并突出未来研究的领域.
主要方法:
- * 在五个主要数据库 (Medline,Embase,科学网,Scopus,medXriv/bioXriv) 进行了系统的文献搜索.
- * 遵守PRISMA和SWiM指南,以报告审查结果.
- *包括8项专注于长期COVID中DNA甲基化和miRNA表达的研究.
主要成果:
- * 六项研究研究了DNA甲基化,两项研究在长期COVID中探索了miRNA表达.
- *包括在内的研究一般具有较小的样本规模和低到相当的质量,患者群体的表征有限.
- *DNA甲基化研究表明,免疫系统,自主神经系统和细胞代谢在PACS/长期COVID病理生理学中的参与.
结论:
- *表观遗传变化可能阐明PACS和长COVID机制,促进患者分组和个性化治疗策略.
- *目前的证据是有希望的,但有限的,需要进一步严格的研究.
- *未来的研究应该利用纵向设计和详细的患者特征,以推进理解,并可能有利于ME/CFS等相关疾病.
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