在活体捐赠者肝移植中,单剂量与双剂量巴西利克西马布诱导疗法的评估
Benjamin N Herrmann1, Cody A Moore1, Heather J Johnson1,2
1Department of Pharmacy, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Clinical transplantation
|October 22, 2024
概括
一次剂量巴西利克西马布在肝移植接受者中具有稳定的功能,与两次剂量一样有效,显著降低了成本和AKI发生率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
- 药物经济学 药物经济学
背景情况:
- 巴西利克西马布是一种昂贵的诱导剂,用于肝移植接受者.
- 标准方案涉及两剂,影响整体治疗费用.
研究的目的:
- 为了比较单剂量和双剂量巴西利克西马布疗法之间的结结果.
- 在活体捐赠者肝移植接受者 (LDLTRs) 中评估降低巴西力西马布剂量的安全性和有效性.
主要方法:
- 在移植后第5天对231名具有稳定的功能 (血清肌素<1.5 mg/dL) 的成年LDLTR进行了回顾性分析.
- 主要终点:从第5天到第30天血清肌素的变化.
- 二级终点:急性损伤 (AKI),排斥,感染和成本节省.
主要成果:
- 单剂和双剂组之间血清肌素变化没有显著差异 (p=0.08).
- 在一次剂量组中,AKI的发病率较低 (39.0%对56.9%,p=0.01).
- 感染率和排斥率相似;单剂量巴西利西马布的实质性成本节省.
结论:
- 单剂量巴西利克西马布是一种安全有效的替代方案,可用于稳定的功能LDLTRs的两剂量.
- 降低巴西利克西马布剂量可显著降低药物成本,而不会影响脏或移植结果.
关键词:
急性细胞排斥 细胞排斥急性脏损伤急性脏损伤是什么这就是Basiliximab.诱导性免疫抑制是一种诱导性免疫抑制.肝脏移植 肝脏移植 肝脏移植 肝脏移植活体捐赠者的肝脏移植药物经济学 药物经济学更多相关视频
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