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新生儿SARS-CoV-2mRNA疫苗接种效率受到母亲抗体的影响

Amy Schumer¹, Elizabeth A Bonney¹, Ethan Harby²

¹Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Vermont Medical Center, Burlington, Vermont, USA.

American journal of reproductive immunology (New York, N.Y. : 1989)

|October 22, 2024

概括

针对SARS-CoV-2的孕产妇疫苗接种可能最初会杀新生儿对mRNA疫苗的抗体反应. 然而,幼会发展出保护性抗体特异性,这表明疫苗在新生儿中有效.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
病毒学病毒学

背景情况:

在怀孕期间对母亲进行疫苗接种可以防止感染.
母亲抗体可能会抑制新生儿抗体的产生.
母亲SARS-CoV-2疫苗接种对新生儿对mRNA疫苗的反应的影响需要调查.

研究的目的:

确定母体疫苗接种对新生儿对SARS-CoV-2mRNA疫苗的免疫反应的影响.
评估mRNA-脂质纳米粒子 (LNP) 疫苗接种是否会引起新生儿新生儿抗体反应,尽管存在母体抗体.

主要方法:

雌性小鼠接种了SARS-CoV-2尖端受体结合域 (RBD) mRNA-LNP的疫苗.
接种疫苗和未接种疫苗的母婴在21天大时被mRNA-LNP接种.
使用ELISA分析了高峰特异性IgG水平和抗体结合特异性.

主要成果:

接种疫苗的母的幼在3周后显示出高峰特异性IgG,高于未接种疫苗的母的幼.
新生儿疫苗接种导致12周未接种疫苗的母婴的高峰特异性IgG.
接种疫苗的母和3周后的幼之间的抗体特异性相似,在15周后,亲和力演变.

结论:

以前存在的母体抗体可能会部分减少新生儿对mRNA-LNP疫苗的初始抗体反应.
这种疫苗接种策略并不能阻止新生儿的保护性抗体特异性的发展.
新生儿mRNA疫苗接种可以引起随后的保护性免疫反应.

关键词:

在SARS-CoV-2中.接种mRNA疫苗的方法母亲的抗体对母体的抗体.新生儿免疫力新生儿免疫力怀孕怀孕怀孕怀孕怀孕垂直传输的垂直传输方式

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