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Updated: Jun 9, 2025

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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新TCR:一个实验支持的功能新抗原特异性TCR序列的免疫信息数据库

Weijun Zhou1,2, Wenting Xiang3, Jinyi Yu2

  • 1Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.

Genomics, proteomics & bioinformatics
|October 22, 2024
PubMed
概括

新抗原特异性T细胞受体 (TCRs) 对于有效的癌症免疫疗法至关重要. 一个新的数据库,NeoTCR,统一了这些TCR的分散数据,帮助研究和开发.

关键词:
在CDR3中,CDR3是指CDR3中的CDR3.数据库数据库数据库是一个数据库.免疫治疗是一种免疫疗法.新抗原是一种新抗原.T细胞受体受体的 T 细胞受体.

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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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