在32种癌症类型中综合素家族的综合性表征
Cheng Zou1, Jinwei Zhu1, Jiangling Xiong1
1Hunan Key Laboratory of Animal Models and Molecular Medicine, School of Biomedical Sciences, Hunan University, Changsha 410082, China.
Genomics, proteomics & bioinformatics
|October 22, 2024
概括
整合素基因变异在癌症中很常见,并且经常促进瘤生长. 一个新的integrinScore系统有效地识别了侵略性瘤,并预测了免疫疗法反应,有助于向治疗的开发.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 综合素基因在瘤发生过程中起着至关重要的作用.
- 目前缺乏对整合蛋白家族成员及其相互作用组的全面泛癌分析.
研究的目的:
- 系统地分析32种癌症类型的整合蛋白家族.
- 开发一种临床工具,用于评估单个瘤中的整合蛋白信号传递.
- 探索针对整合蛋白信号的潜在治疗策略.
主要方法:
- 在大约1万个瘤中对整合素家族变异和表达的系统分析.
- 开发用于整合信号的加权评分系统 (integrinScore).
- 整合素Score与瘤特征,分子亚型和免疫治疗反应的相关性分析.
- 挖掘药物数据库,寻找针对整合素信号的化合物.
- 构建了泛癌综合素探索器 (PIExplorer) 数据库.
主要成果:
- 整合素的改变和失调是常见的,并且在癌症中通常是原始的.
- 整合素表达失调,而不是突变,识别出具有高增殖率和干度的侵袭性瘤.
- 集成Score有效地与分子亚型,瘤攻击性,增殖,茎状,瘤微环境,转移和免疫特征相关联.
- IntegrinScore可以预测患者对免疫治疗的反应.
- 确定了许多针对整合素信号的化合物.
结论:
- 集成蛋白是瘤发生过程中的关键参与者,具有上下文依赖的调节机制.
- 整合分数作为一个有价值的工具来分层瘤和预测临床结果.
- 这项研究为开发整体向治疗提供了全面的资源和理由.
相关概念视频
01:10Integrins
3.8K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
3.8K
01:15Activation of Integrins
3.3K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
3.3K
01:17Intracellular Signaling Affects Focal Adhesions
2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.6K
01:25Selectins
3.3K
Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
3.3K
01:20Cell Adhesion Molecules - Types and Functions
6.6K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved...
CAM Families
The Integrin family of proteins is primarily involved...
6.6K
02:30Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K