安德روج因协会关于丸激素治疗心血管风险的立场论文.
Abraham Morgentaler1, Sandeep Dhindsa2, Adrian S Dobs3
1Division of Urology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Mayo Clinic proceedings
|October 22, 2024
概括
疗法 (TTh) 不会增加诸如心脏病发作或中风等重大心血管不良事件 (MACE) 的风险. TRAVERSE研究证实了TTh的安全性,与广泛的先前研究保持一致.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 之前的观察性研究 (2013-2014) 表明丸激素治疗 (TTh) 增加了心血管风险.
- 这些研究导致2015年FDA在TTh标签上发布了心血管警告.
- 美国食品和药物管理局授权TRAVERSE试验来评估TTh的心血管安全性.
研究的目的:
- 评估丸激素治疗 (TTh) 的心血管安全性.
- 确定TTh是否会增加高心血管风险男性发生重大心血管不良事件 (MACE) 的风险.
主要方法:
- 在TRAVERSE试验中,有5246名有MACE高风险的男性随机接受每日丸激素凝或安慰剂.
- 参与者被跟踪平均33个月.
- 评估的结果包括MACE (心肌梗塞,中风,心血管死亡) 和静脉血栓事件.
主要成果:
- 与安慰剂相比,疗法 (TTh) 与MACE的风险增加无关.
- 没有观察到TTh与静脉血栓事件的风险增加.
- 这些发现与大量现有文献,包括元分析,是一致的.
结论:
- 疗法 (TTh) 与重大心血管不良事件 (MACE) 的风险增加无关.
- 该TRAVERSE研究提供了TTh心血管安全性的明确证据.
- 雄激素协会得出结论,TTh对于心脏病发作,中风和心血管死亡风险是安全的.
更多相关视频
02:47Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
Published on: May 12, 2023
1.3K
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
12.1K
相关概念视频
01:26Testosterone: Functions and Regulation
566
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
566
01:26Atherosclerosis III: Management
1
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
1
01:17Hormonal Regulation of Blood Pressure
2.5K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.5K
01:30Coronary Artery Disease I: Introduction
3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
01:20Disorders of the Male Reproductive System
342
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
342
01:27Atherosclerosis II: Clinical manifestations and prevention
1
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
1