探索Zfp521/ZNF521对初级造血干细胞/原生细胞和白血病进展的贡献

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Emanuela Chiarella1

  • 1Laboratory of Molecular Haematopoiesis and Stem Cell Biology, Department of Experimental and Clinical Medicine, University "Magna Græcia", 88100, Catanzaro, Italy. emanuelachiarella@unicz.it.

Cell and tissue research
|October 22, 2024
PubMed
概括

指蛋白521 (ZNF521) 调节了造血干细胞 (HSC) 的自我更新和分化. 它的上调与MLL-AF9急性髓性白血病 (AML) 有关,它促进白血病细胞的生长,是潜在的治疗标.

关键词:
急性髓性白血病 (AML) 是一种疾病.造血干细胞 (HSCs) 是一种细胞.在MLL-AF9基因融合基因.骨髓和淋巴细胞分化的分化.转录因子 转录因子在Znf521/Zfp52121中使用.t (9;11) 的时间.

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