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通过N-糖蛋白组学发现生物标志物

Rajesh Kumar1, Abhishek Kumar2,3

  • 1Serox GmbH, Mannheim, Germany. rajesh.mukesh.naga@gmail.com.

Methods in molecular biology (Clifton, N.J.)
|October 22, 2024
PubMed
概括

研究关键蛋白质修饰N相关的糖化,有助于理解细胞调节和疾病. 基于质谱的蛋白质组学可以识别异常的N链 glycopeptides 作为早期临床检测的新型癌症生物标志物.

关键词:
基于质谱的蛋白质组学,SPEG,N链 glycopeptide,LC-MS/MS,癌症诊断,发现癌症生物标志物.

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Protein Glycosylation01:25

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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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