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蒙特卡洛剂量计算用于动态变形解剖学的光子和电子辐射疗法

Björn Zobrist¹, Jenny Bertholet¹, Daniel Frei¹

¹Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.

Medical physics

|October 22, 2024

概括

针对蒙特卡洛 (MC) 剂量计算的新型可变形的声素几何学,DefVoxMC,准确地解释了放射治疗期间患者解剖学的变化. 这种方法表明,呼吸运动显著影响肺癌和乳腺癌治疗的剂量分配和计划质量.

科学领域:

医学物理医学物理
辐射疗法辐射疗法
计算剂量计计算剂量计.

背景情况:

在放射治疗中,准确的剂量计算对于有效的治疗计划至关重要.
蒙特卡洛 (MC) 方法是模拟粒子运输和剂量分配的黄金标准.
患者的动态解剖学变化引入不确定性,影响递送剂量的准确性.

研究的目的:

为MC剂量计算 (DefVoxMC) 开发和验证一个可变形的voxel几何.
将动态解剖变形纳入光子和电子辐射疗法剂量计算.
评估DefVoxMC对临床相关治疗计划的影响.

主要方法:

DefVoxMC将voxel几何分解为十二面体,允许使用变形向量场 (DVF) 进行变形.
集成到瑞士蒙特卡洛计划 (SMCP) 中,用于在可变形几何上计算MC剂量.
通过模拟患者运动的in silico测试 (压缩,Fano) 和幻影测量 (Delta4,EBT4膜) 进行验证;使用4DCT衍生DVF研究的临床病例.

主要成果:

在动态变形患者解剖学上,DefVoxMC成功启用了MC剂量计算.
在和幻影测试显示高一致 (>95%GPR) 与预期结果 (在1.0%和0.1%的压缩和法诺测试).
临床上相关的病例显示,由于呼吸运动而导致显著的剂量变化 (肺部增加高达26.9 Gy),减少目标覆盖率 (V95%高达4.2%).

结论:

在动态变形解剖学中开发了一种新的验证方法 (DefVoxMC) 用于MC剂量计算.
呼吸运动显著影响放射治疗计划中的剂量计质量.
DefVoxMC提供了一个工具来准确评估和潜在地减轻这些运动诱导的剂量不确定性.

关键词:

蒙特卡罗的蒙特卡罗是一个非常好的城市.非刚性B-Spline注册登记方式这就是为什么VMAT VMAT.可变形的 voxel 几何形状剂量计算剂量计算方法在变形解剖学上进行剂量重建.电子疗法是一种电子疗法.

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