对于乳腺癌幸存者的更年期激素治疗
1Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
Current opinion in obstetrics & gynecology
|October 22, 2024
概括
在乳腺癌幸存者中,管理更年期症状对于生活质量至关重要. 虽然非激素治疗是首选的,但严重的病例可能需要讨论激素治疗的风险和益处.
科学领域:
- 在瘤学瘤学.
- 妇科 妇科 妇科 妇科
- 更年期管理管理
背景情况:
- 全球乳腺癌发病率正在上升,需要改善治疗后的生活质量.
- 癌症治疗通常会引起严重的绝经症状,可能导致治疗中止.
- 有效地管理这些症状是全球健康面临的重大挑战.
研究的目的:
- 审查目前关于管理乳腺癌幸存者的更年期症状的证据.
- 在这个人群中评估激素和非激素治疗的风险和益处.
- 为临床决策提供有关症状管理和治疗坚持的信息.
主要方法:
- 随机对照试验和观察性研究的系统审查.
- 对更年期激素治疗 (MHT) 和乳腺癌复发的数据的分析.
- 系统性与局部雌激素治疗效果的评估.
主要成果:
- 关于全身MHT风险和乳腺癌复发的数据存在矛盾;激素受体状态是一个关键因素.
- 局部雌激素的全身吸收不能可靠地预测复发.
- 临床数据显示,局部疗法没有持续增加复发风险.
结论:
- 非荷尔蒙治疗是治疗更年期症状的第一线治疗方法,以尽量减少更年期复发的风险.
- 严重的症状不响应非激素疗法需要多学科的方法.
- 讨论激素治疗的证据对于耐药病例的以患者为中心的护理至关重要.
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