母亲的饮食障碍,体重指数和子女的精神病诊断
Ida A K Nilsson1,2,3, Judit Ozsvar1,2, Mika Gissler1,2,4,5
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
JAMA network open
|October 22, 2024
概括
孕产妇的饮食障碍和妊娠前体重指数 (BMI) 超出正常范围,与后代精神疾病的增加有关. 这些风险在孕产妇的饮食障碍中更为明显,这突显了临床考虑的必要性.
科学领域:
- 生殖健康 生殖健康
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 母亲的营养显著影响胎儿的发育.
- 饮食失调和怀孕前的体重指数 (BMI) 可能会影响后代的精神健康.
研究的目的:
- 调查母亲饮食障碍和孕前BMI与后代精神病诊断之间的关联.
主要方法:
- 使用芬兰国家登记册进行基于人口的队列研究 (2004-2014年出生,2021年后续).
- 考克斯的比例危险建模调整为共变量.
- 对不良出生结果和伴随性后代饮食障碍的分层分析.
主要成果:
- 母亲的饮食障碍,体重不足和超重/肥胖与大多数后代的精神病诊断有关.
- 孕产妇的饮食障碍对睡眠,社会功能和动障碍的效果尺寸更大.
- 严重的孕产妇肥胖与后代智力障碍有关;不利的出生结果放大了养和行为障碍的风险.
结论:
- 患有饮食障碍或异常孕前BMI的母亲的后代面临更高的精神疾病风险.
- 孕产妇饮食障碍的风险比单独的BMI更大.
- 对这些母性因素的临床考虑对于预防后代精神疾病至关重要.
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