乳腺癌治疗后2型糖尿病的风险:丹麦的一项基于人口的队列研究
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Kasper A Kjærgaard1,2, Astrid Kousholt1, Reimar W Thomsen1
1Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
乳腺癌 (BC) 幸存者患2型糖尿病 (T2D) 的风险略有增加,特别与癌症治疗有关. 这种过度风险是暂时的,也可能受到其他因素的影响,例如肥胖.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 乳腺癌 (BC) 诊断后的2型糖尿病 (T2D) 风险是一个新兴的问题.
- 之前的研究在样本大小,随访时间和考虑当代治疗方法方面存在局限性.
- 了解这种风险对于为BC幸存者制定有效的预防策略至关重要.
研究的目的:
- 在BC诊断后评估女性T2D风险.
- 为了比较BC幸存者和无癌症妇女之间的T2D风险.
- 调查特定BC治疗与T2D风险之间的关联.
主要方法:
- 丹麦的一项基于人口的队列研究包括1996-2021年期间诊断的早期BC患者.
- 癌症和T2D无患妇女的比较队列与BC患者相匹配.
- 随访延长到T2D诊断,移民,死亡或2022年底,使用Cox模型进行分析.
主要成果:
- 在BC幸存者中,T2D的5年累积发病率为3.8%,对照组为3.3%.
- 在BC幸存者中,T2D的调整后危险比为1.20在5年和1.09在15年.
- 辅助性内分泌治疗 (特别是芳酶抑制剂),化疗和放射治疗与T2D风险增加有关.
结论:
- 乳腺癌与T2D的风险过高,尽管中等,相关.
- 增加T2D风险似乎是暂时的,与BC治疗有关.
- 肥胖和诊断活动增加等因素也可能影响观察到的风险.
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