Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

LGBTQ+ Realities in the Biological Sciences.

CBE life sciences education·2026

Same author

Outcomes after elective total aortic arch replacement: Does obesity matter?

JTCVS open·2026

Same author

Mindful diagnostics in culture-negative endocarditis: early noninvasive diagnosis of <i>Tropheryma whipplei</i> by plasma microbial cell-free DNA.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026

Same author

Rethinking flow: the paradox of renoprotection without increased renal blood flow in cardiopulmonary bypass.

Journal of thoracic disease·2026

Same author

Concomitant bilateral lung transplantation and diaphragmatic hernia repair: A case report.

JTCVS techniques·2026

Same author

Ten-year outcomes of valve-replacing versus valve-sparing aortic root replacement in patients with Marfan syndrome: An observational multicenter study.

The Journal of thoracic and cardiovascular surgery·2026

Search research articles

相关实验视频

Updated: Jun 9, 2025

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

机器学习辅助中风预测在机械循环支持:系统性线粒体功能障碍的预测作用.

Jacob P Scioscia¹, Ivan Murrieta-Alvarez¹, Shiyi Li¹

¹From the Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

ASAIO journal (American Society for Artificial Internal Organs : 1992)

|October 22, 2024

概括

在LVAD植入之前,先前患有中风的患者显示线粒体功能障碍. 通过氧化酸化蛋白来测量这种功能障碍,可以预测CF-LVAD手术后的新中风.

更多相关视频

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Published on: July 7, 2023

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

相关实验视频

Last Updated: Jun 9, 2025

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Use of a Foot-Induced Digitally Controlled Resistance Device for Functional Magnetic Resonance Imaging Evaluation in Patients with Foot Paresis

Published on: July 7, 2023

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

科学领域:

心脏病学心脏病学
神经学神经学
线粒体生物学线粒体生物学

背景情况:

在接受连续流动左心室辅助器件 (CF-LVADs) 的高级充血性心力衰竭 (CHF) 患者中,中风风险很大.
线粒体氧化酸化 (OxPhos) 异常与神经退行和脑缺血有关.

研究的目的:

为了调查是否之前的中风与CF-LVAD患者的系统性线粒体OxPhos异常有关.
为了确定这些异常在患有植入后新中风风险的患者中是否更明显.

主要方法:

研究了50名CF-LVAD患者 (25人先前患有中风,25人没有).
在CF-LVAD植入前和后的血白细胞中测量了OxPhos复合蛋白 (C.I-C.V).
利用机器学习 (LASSO,随机森林) 进行中风预测建模.

主要成果:

与没有中风的组相比,前中风组的OxPhos蛋白 (C.I,C.II,C.IV,C.V) 含量明显较低,无论是在CF-LVAD前后.
在CF-LVAD后的中风前组中,OxPhos蛋白进一步下降.
机器学习模型确定了六个预后因素,实现了0.93的AUC,用于预测术后中风.

结论:

线粒体功能障碍,指的是外周OxPhos蛋白减少,存在于CHF患者之前的缺血性中风甚至在CF-LVAD植入之前.
减少OxPhos蛋白表达可能作为CF-LVAD植入后新中风的预测生物标志物.