发展和扩大已故器官捐赠的最大治疗潜力:从2023年桑坦德峰会开始,可行的全球挑战
Dale Gardiner1, Andrew McGee2, Ali Abdul Kareem Al Obaidli3
1Organ and Tissue Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom.
Transplantation
|October 22, 2024
概括
为了实现全球器官捐献自给自足,需要基于大脑功能停止的统一死亡定义. 通过先进的输液技术,通过循环死亡确定 (DCDD) 后扩大捐赠也至关重要.
科学领域:
- 移植医学 移植医学
- 生物伦理学生物伦理学
- 公共卫生政策 公共卫生政策
背景情况:
- 全球峰会"转移全球趋同"讨论了器官捐献方面的挑战.
- 已故捐献是实现全球器官移植自给自足的关键.
- 工作组2确定了扩大已故器官捐献的关键障碍.
研究的目的:
- 总结了在桑坦德峰会上由工作组2确定的主要挑战.
- 提出解决方案,以实现在器官捐赠和移植领域的全球趋同.
- 概述增加已故器官捐献和器官利用的策略.
主要方法:
- 该研究总结了全球峰会第二工作组的讨论和建议.
- 它侧重于两个主要挑战:定义死亡和扩大循环死亡确定 (DCDD) 后的捐赠.
- 描述了实施拟议战略的建议.
主要成果:
- 挑战1:需要一个统一的全球死亡概念,以永久停止大脑功能为中心.
- 挑战2:减少差距和增加器官利用需要扩大DCDD.
- 扩大的DCDD可以通过in situ常热区域 perfusion和ex situ机器 perfusion来实现.
结论:
- 为了推进移植,全球统一的死亡定义至关重要.
- 通过DCDD增加器官利用率,在 perfusion 技术的支持下,对于自给自足至关重要.
- 实施这些战略需要全球合作和共识.
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