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Updated: Jun 9, 2025

Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO
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Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO

Published on: December 28, 2019

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在IKZF1无序区域中保存的螺旋形图案调解了NuRD相互作用和转录抑制

Tianyi Zhang1, Yi-Fang Wang1, Alex Montoya1

  • 1Medical Research Council Laboratory of Medical Sciences, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom.

Blood
|October 22, 2024
PubMed
概括

转录因子Ikaros指1 (IKZF1) 主要与核心压缩器相互作用,导致B细胞急性淋巴细胞白血病 (B-ALL) 的快速基因沉默和减少扩散. 这种机制对IKZF1至关重要.

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