体重指数和饮食模式之间的相互作用对严重的NAFLD发病率的影响:前性队列研究
Yuxiao Wang1, Jing Li2, Congying Song3
1School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China; Institute of Occupational Hazard Assessment, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, PR China; Department of Blood Transfusion, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China.
Clinical nutrition (Edinburgh, Scotland)
|October 22, 2024
概括
饮食模式显著影响非酒精性脂肪性肝病 (NAFLD) 风险,相互作用因体重指数 (BMI) 而有所不同. 谨慎的饮食可能会降低风险,而以肉为基础的饮食会增加风险,特别是在BMI较高的个体中.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 饮食模式与非酒精性脂肪性肝病 (NAFLD) 风险之间的关系,特别是严重的形式,需要澄清关于体重指数 (BMI) 的影响.
- 研究BMI特定的关联对于理解NAFLD发展和预防策略至关重要.
研究的目的:
- 检查主要饮食模式与严重NAFLD发病率之间的关联.
- 为了确定BMI是否改变饮食模式对严重NAFLD风险的影响.
主要方法:
- 一项前性队列研究,利用来自白人参与者的英国生物库数据.
- 主要成分分析 (PCA) 从食物频率问卷 (FFQ) 数据中确定了饮食模式.
- 因果特异性考克斯回归和因相互作用而导致的相对过度风险 (RERI) 评估的关联和BMI相互作用.
主要成果:
- 在12.68年的时间里,在307,130名参与者中发现了3104例严重的NAFLD病例.
- 谨慎的饮食 (RC1) 与严重的NAFLD风险降低有关 (HR 0.91),而以肉为基础的饮食 (RC2) 与风险增加有关 (HR 1.10).
- 在BMI (≥25 kg/m2) 和两种饮食模式之间观察到显著的相互作用 (RC1:RERI -0.22;RC2:RERI 0.29).
结论:
- 饮食模式在严重的NAFLD发病率中起着至关重要的作用.
- 体重指数显著改变了饮食模式和严重的NAFLD之间的关联.
- 考虑到BMI的个性化饮食建议对于预防NAFLD至关重要.
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