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发现了用于免疫检查点蛋白的自-溶酶体降解的小分子

Kaizhen Wang1, Zhihao Qi2, Jiazheng Guo2

  • 1Department of Biomedical Engineering and Diagnostic Pharmacy, School of Engineering, China Pharmaceutical University, Nanjing, 210009, China.

European journal of medicinal chemistry
|October 22, 2024
PubMed
概括

研究人员开发了一种新的策略,使用小分子通过自酶体通路降低免疫检查点,克服了目前针对PD-L1.1.等跨膜蛋白的向蛋白降解 (TPD) 技术的局限性.

关键词:
自 - 溶解体自 - 溶解体自癌症免疫疗法癌症免疫疗法降解器降解器降解器在PD-1/PD-L1中.在视野中看到的.

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